Nano-Suspension: A Novel and Emerging Approach in Pharmaceutical Drug Delivery

Nano-suspension, are nano-sized colloidal particle systems. Nano-suspension can be understood as the sub-micron colloidal dispersions of p’ceutical active ingredient particles in a liquid phase, with a size less than 1 micrometre, without any matrix material. These nano-suspensions are stabilized by the use of various surfactants and polymers. Nano-suspensions are distinguishable from nanoparticles and solid lipid nanoparticles. Nanoparticles are polymeric colloidal carriers of the drug, while solid lipid nanoparticles are lipid-based carriers of drugs. They have recently become one of the most engaging substances in nano-pharmaceuticals. Nano-suspension have prominent commercial potential since they provide the enhanced solubility and dissolution of poor water soluble drugs by means of their small particle sizes and large surface areas. Moreover, they can alter the p'kinetics of the drug improving its efficacy and safety. These benefits can be used to enhance the bioavailability of poorly soluble drugs in dermal, oral, or systemic administration routes. The selection of stabilizer types, including surfactants and/or polymers, and their precise ratio are the most crucial factors in the formulation of nano-suspension. The delicate balance of stabilizers and the choice of fabrication method are paramount in determining the success and performance of nano-suspensions. This review article helps us gain further detailed insight on nano-suspensions as a novel drug delivery system. [1]