Crafting and Advancements of Pippali and Cissus Quadrangularis Anti- Inflammatory & Anti-Rheumatic Herbal Ointment

Crafting and Advancements of Pippali and Cissus Quadrangularis Anti-Inflammatory & Anti-Rheumatic Herbal Ointment” Are Viscous semi-solid formulations called ointments are applied externally to the skin or mucous membranes. Using two traditional medicinal herbs, Cissus quadrangularis and pippali (long pepper), the study's objective was to create and assess an herbal ointment having anti- inflammatory and anti-rheumatic qualities. A fusion technique and trituration were used for the preparation. Throughout the development phase, three distinct formulations were used: Placebo: This formulation was made as a control and contained no active component, Pippali was incorporated into the formulation for F-1 (Pippali-based formulation). This resulted in a black-looking ointment. F-2 (formulation based on Cissus quadrangularis): Pippali was swapped out for Cissus quadrangularis in this formulation. When the dark green ointment was applied to the skin, it caused a slight easing of pain. F-3 & F-4 (Combined formulation): By combining Pippali and Cissus quadrangularis, this formulation improved absorption and bioavailability while also enhancing anti-inflammatory and anti-rheumatic properties. With a pH of 5.9, this ointment was determined to be well-balanced and skin-friendly. The prepared ointments exhibited good appearance, spread ability, and stability under typical storage conditions. Importantly, the combined formulation (F- 4) displayed major anti-inflammatory effects and effectively reduced inflammation, while the reference drug alleviated pain. No skin irritation or phase separation occurred during storage, indicating that the ointment is safe for topical use. Pippali, recognized for its pain-relieving and anti-inflammatory effects, was incorporated into the formulation for its ability to diminish swelling and inflammation and alleviate pain. The developed herbal ointment, containing Pippali and Cissus quadrangularis, proved to be a stable, effective, and safe product for topical use, exhibiting promising anti-inflammatory and anti-rheumatic properties. The formulation was well-tolerated on the skin, showing no signs of irritation or phase separation, and demonstrated beneficial effects in reducing inflammation and pain.