POLYMORPHISM OF HLA-DQA1, HLA-DQB1, AND HLA-DRB1 GENES AND THEIR CLINICAL SIGNIFICANCE

This article investigates the polymorphism of HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes and their clinical significance. The study involved 220 blood samples from healthy individuals, with molecular genetic analysis used to identify the alleles of HLA class II genes. The results demonstrated an asymmetric distribution of these alleles. HLA-DQA15*01, HLA-DQB1*02, and HLA-DRB1*07 were identified as the most prevalent alleles. The findings highlight the significance of these results in evaluating immunological compatibility in autoimmune diseases, allergic conditions, and organ transplantation.