Review on Transdermal drug delivery focus on Recent trend of Microneedle in transdermal patch its current and future advancement

Transdermal drug delivery offers an appealing option to oral administration and has the potential to serve as a substitute for hypodermic injection as well. For centuries, individuals have applied substances onto the skin to achieve medicinal benefits, and in the present day, a range of topical formulations have been created to address local medical issues. Transdermal drug delivery has significantly influenced medical practice; however, it has not yet reached its full potential as a substitute for oral administration and hypodermic injections. First-generation transdermal systems have seen a consistent rise in clinical applications for the administration of small, lipophilic, low-dose medications. Meanwhile, second-generation systems that incorporate chemical enhancers, nonactivational ultrasound, and iontophoresis have also led to the development of clinical products, with iontophoresis offering the advantage of real-time control over delivery rates. Third-generation systems focus on the skin's barrier layer, the stratum corneum, employing techniques such as microneedles, thermal ablation, microdermabrasion, electroporation, and cavitational ultrasound. Currently, microneedles are advancing through clinical trials aimed at delivering macromolecules and vaccines, including insulin, parathyroid hormone, and the influenza vaccine. With the implementation of these innovative second- and third-generation enhancement methods, transdermal delivery is set to greatly enhance its role in the field of medicine. In present we discussed the transdermal drug review and mainly focus on recent developed microneedle for transdermal delivery.