Targeting Glioblastoma: Inducing Necroptosis molecular pathway Post- Photodynamic Therapy for Enhanced Neurosurgical and Therapeutic Outcomes

Abstract Glioblastoma (GBM) remains a formidable challenge in neurosurgery and oncology due to its aggressive progression and resistance to standard therapies. This study investigates the potential of enhancing photodynamic therapy (PDT) efficacy by inducing necroptosis—a regulated form of necrotic cell death—in glioblastoma stem cells (GSCs). We hypothesize that combining PDT with necroptosis induction could overcome the limitations of conventional approaches by targeting resistant tumor cell populations, ultimately improving clinical outcomes. This work provides insights into the molecular mechanisms underlying this combinatorial strategy and its potential translational impact in GBM treatment.