Long-Term Clinical Evolution of McCune-Albright syndrome: 15 years of follow-up

<div>Mc Cune Albright syndrome is a rare, sporadic disorder manifested by the triad of fibrous bone dysplasia (FD), café-au-lait skin spots and precocious puberty (PP), which may be associated with other hormonal hyperfunctions.  The broad spectrum of manifestations reflects the mosaicism of the activating somatic mutation of the GNAS gene in different tissues.</div> <div> Follow-up of patients with Mc Cune Albright syndrome in adulthood remains essential, and requires multidisciplinary management, as this population remains susceptible to sometimes serious complications related to the hyper-secretory nature of all possible endocrine conditions.  We report the case of a 15-year-old female patient with complete Mc Cune Albright syndrome since the age of 9 months.</div>