Trypanosoma cruzi: A Molecular Deconstruction of Chagas Disease

The objective of this review article is to compile high-quality information related to the molecular aspects surrounding the parasite Trypanosoma cruzi, to obtain a molecular perspective. The PubMed database was consulted, and this article included documents published within the last five years. Additionally, some older documents with a well- founded and significant basis were considered. Other search filters included the following keywords: molecular aspects of Trypanosoma cruzi, Trypanosoma cruzi immune. The general search results generated 3,286 documents; 2,761 were excluded due to being older than five years, and another 415 were excluded for not being review articles. This left a total of 110 articles for consideration, of which 25 were consulted to support and develop this article. The strategy for searching and selecting relevant articles involved reading the abstracts. The theoretical analysis-synthesis method was used for the search and processing of empirical, theoretical, and methodological information, aiming to break down the information to extract the essential aspects of the subject of study and progressively contribute to solving the scientific problem. This article provides information on different aspects and offers a molecular perspective on the mechanism of action of Trypanosoma cruzi in the human body and how it fights for its survival at the expense of ours.