In Vitro Anthelmintic and Hemolytic Potential of Lantana Camara: A Pharmacological Study

To study and investigate the L. camara Leaves for their anthelmintic and hemolytic activity using Earthworm(Eisenia Fetida) and human erythrocytes, respectively. Methods: The different successive extracts, i.e., chloroform, ethanol, and aqueous extract of L camera leaves, were used on E. fetida as a test worm. The other concentrations (250,500,750µg/ml) of various extracts were tested for bioassay, which involved the determination of paralysis and death time of worms. Albendazole was used as standard, and normal saline was used as a control. Hemolytic activity was carried out by different solvent extracts (chloroform, hexane: ethyl acetate, aqueous, pet ether) and Vit C as a standard drug. Results: The anthelmintic activity of the leaves LC is done using different extracts like aqueous, ethanol, and chloroform. The chloroform extract gave higher anthelmintic activity than the aqueous extract, and the hemolytic activity of the leaves LC is done using different solvent extracts like chloroform, hexane: ethyl acetate aqueous and petroleum ether. There is no activity of aqueous extract but petroleum ether shows more activity. Conclusion: In this study, we reported that L. camara leaf extract in the presence of chloroform has more anthelmintic activity than Albendazole suspension (Synthetic drug). This concludes that the L. camara plant leaf is more beneficial and active than albendazole.The hemolytic activity of L. cameraleaves aqueous extract and its various solvent fractionsrevealed that theleaves possess no hemolytic activity in aqueous extract but show high hemolytic activity in the presence of petroleum ether,which can be further usedto isolate bioactive compounds