ASSOCIATION OF GLIOBLASTOMA WITH MENTAL STRESS

Abstract Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, such as anxiety and fear. Chronic stress is thought to impact glioma profoundly. However, because of the complex mechanisms underlying CS and variability in individual tolerance, the role of CS in glioma remains unclear [2]. This review suggests to study deeper potential role of chronic mental stress in gliomas, particularly glioblastoma, etiology, pathogenesis. Mental stress management among population may lead to better results in gliomas prevention and treatment. After diagnosis, glioblastoma [GBM] patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression. However, systematic study about the relationship between depression and GBM progression is still lacking [1]. Given the negative impact of maladaptive psychosocial and biobehavioral factors on normal immune system functions, the question remains as to how psychological conditions potentially affect the brain tumor patient anti-tumor immune response [3]. Since immunotherapy has yet to show efficacy at increasing malignant glioma patient survival in all randomized, phase III clinical trials to-date, this review provides new insights into the potential negative effects of chronic distress on brain tumor patient immune functions and outcomes [3]. Central nervous system [CNS] tumors account for 1.6% of all newly diagnosed cancers worldwide according to Global Cancer Statistics 2020 [4], with gliomas being the most common primary CNS tumors, accounting for approximately 75%. from all detected [5]. In this article we will talk about gliomas and what them belong to chronic stress. How to decrease risk factors of initiation of brain oncology.