Evaluating the Level of Homeobox B8 and its Association with Cell Lung Cancer Proliferation Downregulation: A Systematic Review and Meta-analysis

Background and aim: Homeobox family genes have been identified as cancer growth regulators. There is no meta-analysis or comprehensive study on the activity of Homeobox B8 (HOXB8) in lung cancer. The aim of the present study was to Evaluate the level of Homeobox B8 and its association with cell lung cancer proliferation downregulation.Material and methods: For this systematic review and meta-analysis study, international databases such as MEDLINE (PubMed and Ovid), Web of Science, and Scopus were searched until August 2024 using keywords relevant to the study objectives. STATA/MP. v17 software was used to analyze data.Results: Five studies were reviewed. high HOXB8 level was a risk factor for unfavorable lung cancer patient overall survival (HR = 3.32; 95% CI 2.78, 3.86; p<0.001). The results suggested a shorter survival time for patients with high Homeobox B8 (HOXB8) expression.Conclusions: Homeobox B8 (HOXB8) is highly expressed in lung cancer and associated with overall survival.