Design and Preparing a Topical Semi-solid Formulation of a Combination of Plantago ovata seeds and Rosehip oil to Provide an Analgesic and Anti-inflammatory Medicine

Considering the importance of pain, this study aims to present a standard topical formulation for pain control. In the texts of traditional Persian pharmaceutical books, many verbs, and citrus fruits are mentioned as pain relievers. In this study, the Plantago ovata Forsk. plant was selected from the book of Makhzen al-Adviyah, and related aqueous and acidic extractions were yielded in rose oil. After microscopic characterization and determining the identification number of the plant and FTIR test, Plantago ovata Forsk seed extract was prepared with different acidic and aqueous types, and the mucilage was prepared after evaluating several cream formulations, finally, the proportion of 70% oil and 30% stearic acid contained 65% extract. It was chosen as the appropriate formulation, which was more suitable for appearance characteristics (uniform texture and proper spreading without feeling rough on the skin). The final semi-solid formulation was examined in terms of the uniformity and integrity of the cream and the examination of rubability and cream consistency tests, the examination of spreadability, pH measurement, and the examination of viscosity and rheology properties, and the results showed that this formulation in terms of pharmaceutics tests and the total saccharide content was in the acceptable range. After passing the clinical trials, the mentioned product can be effective as a product derived from herbal compounds for pain control.