Evaluation of skin hydration and anti-itch properties after application of a novel urea-based moisturizing cream

Objectives Moisturizers are crucial in improving skin hydration and reducing transepidermal water loss (TEWL), especially in individuals with dry skin. This study aims to evaluate Venusia Ureka Cream’s efficacy in enhancing skin hydration, reducing TEWL, and providing itch relief in individuals with dry, itchy skin. Materials and Methods This single-center, observational study enrolled participants with dry skin. Participants applied Venusia Ureka Cream at four test sites on their forearms, with four control sites left untreated. Skin hydration and TEWL were measured using the MoistureMeter stratum corneum and VapoMeter, respectively, at baseline, 12, 24, and 36 h after application. Pruritus was assessed using a 10-point Visual Analog Scale at baseline, 6, and 12 h. Results The study included 32 participants (mean age: 28.66 ± 8.68 years; 75% female). Skin hydration improved significantly at occluded test sites, increasing from baseline (10.71 ± 3.45) to 36 h (37.48 ± 16.33; P < 0.001), reaching normal hydration levels, while unoccluded sites showed modest but significant improvement (10.68 ± 3.36–15.23 ± 8.05; P < 0.001). TEWL increased significantly at 24 h under occluded conditions ( P = 0.040), with no significant changes at other time points or under unoccluded conditions ( P > 0.05). Pruritus scores decreased by 54.6% at 6 h ( P < 0.001) and 94.7% at 12 h ( P < 0.001). No adverse reactions were observed. Conclusion Venusia Ureka Cream effectively enhances skin hydration, reduces TEWL, and provides rapid relief from pruritus. The product is well-tolerated and offers sustained hydration, making it a promising solution for individuals with dry, itchy skin.