Showing how growth rate and population growth rate heterogeneity (PGRH) varies between <i>E.coli</i> wildtype WT and Δ<i>tolC</i> strains for two antibiotics, ciprofloxacin and tetracycline.

The mutant has a lower MIC for both ciprofloxacin and tetracycline, but there is no significant difference in PGRH between the two. <b>AB</b> Growth rate vs antibiotic concentration plots for ciprofloxacin and tetracycline. The points show the mean and standard deviation between repeats. There are three repeats per condition. <b>CD</b> Normalizing the antibtioic concentration to IC₅₀ shows how the susecptibility curve differes between the strains. A normalized concentration of 0 corresponds to the IC₅₀, while 1 corresponds to IC₉₀. The vertical lines show the IC₁₀ and IC₉₀ concentrations, respectively. <b>EF</b> shows population growth rate heterogeneity (PGRH) with antibiotic concentration normalised as in CD. (PDF)