S1 Fig -

<p>qPCR analysis of pro-para-inflammatory cytokines <b>(A)</b> gene expression and <b>(B)</b> protein level was compared with the level of osteopontin gene/protein from 4, 8, 13 and 21 weeks old db/db male mice and WT control mice. Data are expressed as the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, [Two-way ANOVA with Tukey’s multiple comparison test]. Note: MMP-9 protein level was not quantifiable at 2 and 4 weeks in WT mice, hence these data are omitted.</p> <p>(PDF)</p>