Cross-resistance of compound 22-evolved clones.

Clones derived from <i>in vitro</i> resistance evolution with compound <b>22</b> (see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012216#ppat.1012216.g002" target="_blank">Fig 2</a>) were evaluated against additional compounds from this series, compounds <b>30</b>, <b>32</b>, <b>33</b> and <b>35</b>. Compound <b>30</b> is a structural isomer of compound <b>31</b> (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012216#ppat.1012216.g002" target="_blank">Fig 2b</a>) and compounds <b>32</b> and <b>33</b> are isomers of each other. Each dot represents a biological replicate (n = 5) with mean±SD shown as bar chart, and statistical significance determined by Mann-Whitney <i>U</i> test (*p < 0.05, **p < 0.01). (PDF)