Anti-ferroptotic potency of PTC-041 compared to other compounds.

<p>Cell survival was assessed by CTG 2.0 assay 24 hours after RSL3 (2 μM) and concomitant compound treatment (24-point dose response). Rescue potency was determined by standard 4-parameter curve fitting (Dotmatics), with the concentration for half-maximal rescue activity (EC50) reported here. The potency of each compound was determined in 3 independent patient fibroblast cultures (ND40070, ND40078, and ND30116). The mean and SEM across the 3 donors’ cells were calculated.</p> <p>(DOCX)</p>