Discretization of the extracellular space surrounding serially connected dendrite segments.

<p>(a) The 10 μm dendritic segments with diameter R<sub>1</sub> = 1 μm were concatenated to create 1 dendrite with total length 110 μm. The surface of the dendrite is unfolded to create a 2D surface where we simulate the movement of K<sup>+</sup>. The segments were either populated with similarly or diversely tuned synapses. Colored points indicate the placement of synapses on a 2D grid around a dendritic segment, and their color represents their target orientation, similar to <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002935#pbio.3002935.g001" target="_blank">Fig 1C</a>. (b) Representation of K<sup>+</sup> efflux from one synapse at different orientations. If a synapse is activated close to its preferred orientation (red line), the total amount of K<sup>+</sup> efflux will be higher than a non-preferred stimulus (black line). Note that tpeak corresponds to the peak of K<sup>+</sup> efflux, occurring after synaptic activation.</p> <p>(PDF)</p>