S1 Text - Analysis of systemic effects of dioxin on human health through template-and-anchor modeling

Fig A. Sensitivities of plasma cholesterol, LDL, and HDL. All relative sensitivities are below 1 in magnitude. Fig B. Results of a local sensitivity analysis for steroidogenesis pathway anchor model. All parameters have a sensitivity coefficient below 1 in magnitude. Fig C. Results of a sensitivity analysis of the template model. All parameters values exhibit changes in the steady-state values of less than 10% in magnitude, corresponding to absolute values of relative sensitivities <1. Fig D. Generic PBPK model as a multiscale structure. The primary scale of granularity reflects organs and tissues, but the drug concentrations in these organs are subject to molecular and cellular events, such as sequestration and degradation in the liver. In this illustration, the drug or toxicant enters the body per inhalation. (DOCX)