Differentially expressed mRNAs in pre-cystic and early cystic mouse kidneys.

<p>(A) Functional enrichment analysis for P6 unique DEGs, P10 unique DEGs, and those common to both lists (CICs). GO, KEGG, Reactome, and WikiPathways databases were probed using g:profiler. Top functions are shown and listed, ranked by p adjusted values. (B) Heatmap comparing differential gene expression for cyst initiation candidates (CICs) in our data (P6, P10) and published pre-cystic mouse data [WP_Pkd2_P7/3/1, WP_Pkd1_P7/3/1 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.ref015" target="_blank">15</a>], ZS [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.ref017" target="_blank">17</a>], KP2/3/6 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.ref016" target="_blank">16</a>]. <i>Tacstd2</i> identified with label and black box. (C) Barplots showing the number of differentially expressed genes (False discovery rate < 0.05) identified in data from the described studies. Our study: P6 and P10 following Pkd2 deletion. Woo <i>et al</i>. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.ref015" target="_blank">15</a>]: P1, P3, and P7 following Pkd1 or Pkd2 deletion. Kunnen <i>et al</i>. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.ref016" target="_blank">16</a>]: Weeks 2, 3, and 6 following Pkd1 deletion. Pkd1 models represented by blue bars). Pkd2 models represented by black bars.</p> <p>(PDF)</p>