Analysis of simple models.

<b>A)</b> Wiring diagram of simple Model 1, which belongs to the class shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g001" target="_blank">Fig 1A</a> left. <b>B)</b> The model shows bistability. It also reproduces the alteration in the bifurcation diagram of APC/C similarly to what seen for the detailed model in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g004" target="_blank">Fig 4A</a>. <b>C)</b> Simulation of the Palframan’s experiment[<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.ref009" target="_blank">9</a>] to show bistability in the simple model, in analogy with <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g001" target="_blank">Fig 1D</a>. <b>D)</b> Stochastic simulations with fixed number of unattached kinetochores give rise to the exponential distribution shown in <b>(E)</b>, in analogy with <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g002" target="_blank">Fig 2D</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g002" target="_blank">2E</a>. <b>F)</b> APC-A mutants decrease the frequency of adaptations upon washout, similarly to <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g004" target="_blank">Fig 4C</a>. <b>G)</b> Wiring diagram of simple Model 2, which belongs to the class shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g001" target="_blank">Fig 1A</a> right. <b>H)</b> The model shows bistability. It also reproduces the alteration in the bifurcation diagram of APC/C similarly to what seen for the detailed model in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g004" target="_blank">Fig 4A</a>. <b>I)</b> Simulation of the Palframan’s experiment [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.ref009" target="_blank">9</a>] to show bistability in the simple model, in analogy with <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g001" target="_blank">Fig 1D</a>. <b>L)</b> Stochastic simulations with fixed number of unattached kinetochores give rise to the exponential distribution shown in <b>(M)</b>, in analogy with <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g002" target="_blank">Fig 2D</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g002" target="_blank">2E</a>. <b>N)</b> APC-A mutants decrease the frequency of adaptations upon washout, similarly to <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012879#pcbi.1012879.g004" target="_blank">Fig 4C</a>. (PDF)