Lpt and ATP synthesis pathway effects in tetracycline-class antibiotics.

Sina plots with boxplots of differential guide CPMs for listed STRING identifiers in tetracycline-class antibiotics: (A) lipopolysaccharide (lipooligosaccharide in A. baumannii) transport or (B) ATP synthesis pathways. Guides are weighted by predicted efficacy, with perfect guides at 100. Chemical interactions compared to no chemical control (up, down, or no change) and FDRs are listed. Non-significant comparisons are shown with grey backgrounds. (C) Chemical structures of tetracycline, minocycline, and tigecycline. (PDF)