Robustness of chosen tuning parameter values w.r.t. endothelial cell morphology.

<p>Reference cell morphometric measurements computed after vessel surface reconstruction with <i>n</i><sub>oct</sub> = 30, λ = 20% and <i>σ</i> = 10 μm. Morphology of each cell re-computed after altering either <i>n</i><sub>oct</sub>, λ or <i>σ</i>, while fixing the other two parameters. Relative deviations dev<sub>rel</sub> of re-computed cell morphometric measurements from their reference values computed with <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011924#pcbi.1011924.e068" target="_blank">Eq (37)</a> (main text); results for pooled EC surfaces from wild-type and Endoglin-deficient embryos at 48 hpf and 72 hpf. <i>f</i>: relative frequency. Note: We omitted the column <i>f</i>(dev<sub>rel</sub> < −10%) as it can be computed as <i>f</i>(dev<sub>rel</sub> < −10%) = 100% − <i>f</i>(|dev<sub>rel</sub>| ≤ 10%) − <i>f</i>(dev<sub>rel</sub> > 10%). When <i>n</i><sub>oct</sub> = 60, the number of cells was 290. In all other computations, the number of cells was 296. <sup>†</sup>: constraint from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011924#pcbi.1011924.e034" target="_blank">Eq (18)</a> (main text) omitted. *: vessel surface not smoothed. When halving or doubling either <i>n</i><sub>oct</sub>, λ or <i>σ</i>, each morphometric measurement differed by maximally 10%. Notably, when not smoothing, larger cell surface areas were computed. As a consequence, elongation was decreased and compactness increased.</p> <p>(PDF)</p>