Study on the changes in dental pulp repair response in rats after direct pulp capping using iRoot BP Plus and MTA

Objective To explore the differences and similarities in the changes of pulp repair response after direct pulp capping with iRoot BP Plus and MTA. Methods A total of 36 male SD rats were randomly divided into 3 groups, namely iRoot BP Plus group, MTA group and blank control group. Dental pulp exposure and direct pulp capping was performed on both sides of maxillary first molars of each rat. Four rats were randomly selected and sacrificed from each group at 7, 14, and 28 days postoperatively, and the specimens were taken for hematoxylin-eosin (HE) staining, and then each index was observed. Results ①From the perspective of dentin tubular formation quality, at 14 d and 28 d, there were statistical differences between iRoot BP Plus group and MTA group(P<0.05), and iRoot BP Plus was significantly better than MTA in terms of quality of restorative dentin formation. ②At 14 days after operation, iRoot BP Plus had a greater area of neodontinin than that in MTA group(P<0.05). Conclusion Both iRoot BP Plus and MTA can promote the formation of restorative dentin bridges after direct pulp capping, and the formation quality is high. The long-term effects need to be further studied.