Challenges and Countermeasures of Medically Unexplained Symptoms

The diagnosis and treatment of medically unexplained symptoms (MUS) is complex and the cost of medical resources is large. MUS is a challenging clinical problem in general practice. The field of MUS is still in the preliminary stage of exploration in China. In this review, we systematically and comprehensively discuss the current challenges of MUS in the aspects of the concept, epidemiological characteristics, pathogenesis, diagnosis and treatment. We also propose some possible countermeasures combined with the actual situation. This article shows that there is no consensus on the concept, mechanism and diagnostic of MUS, suggesting the urgent need to draft relevant clinical guidelines and construct clinical pathways. At present, general practitioners have insufficient ability in the understanding, diagnosis and treatment of MUS, therefore, it is necessary to strengthen the training of MUS competence for general practitioners. More prospective, multi-center and multidisciplinary studies are needed to explore the characteristics and treatment strategies of MUS. This article provides a reference for general practitioners to understand and manage MUS scientifically and effectively.