Surface Charge Redistribution-Induced ElectrochemiluminescenceEnhancement of Gold Nanoclusters: The Novel Generation of EfficientIlluminants

Herein, we developed the agmatine/6-aza-2-thiothymine templated gold nanoclusters (Agm/ATT-Au NCs) as a novel electrochemiluminescence (ECL) illuminant, which exhibited high ECL in the annihilation path via the newly defined <u>s</u>urface <u>c</u>harge <u>r</u>edistribution-<u>i</u>nduced ECL <u>e</u>nhancement (SCRIE). Impressively, the electrochemical redox reaction of Agm/ATT-Au NCs was enhanced owing to the boosted electron transfer kinetics of the illuminant by the positively charged Agm-triggered surface charge redistribution of ATT-Au NCs, resulting in an ∼110-fold higher ECL signal of Agm/ATT-Au NCs than ATT-Au NCs. This work digs deep into the electrogenerated process of the annihilation mechanism to direct the rational design of an efficient illuminant. Moreover, the Agm/ATT-Au NCs as a powerful illuminant was successfully applied in a highly sensitive bioassay platform for detecting glial fibrillary acidic protein (GFAP) with the detection limit down to 27.5 ag/mL, an intense organic light-emitting diode (OLED), and high-definition ECL imaging.