Cu-BTC MOFs Grown\nIn Situ on Poly(ionic liquid)-Based\nElectrospun Fibrous Membranes for Wound Dressings

Developing\nwound dressings with antibacterial, good moisture absorption,\nair permeability and inflammatory inhibition activities to promote\nwound healing effectively is highly desirable in clinical practice.\nHerein, a multifunctional wound dressing with air permeability, hygroscopicity\nand antibacterial activity was developed by in situ growth of a metal–organic\nframework (Cu-BTC) benzene-1,3,5-tricarboxylate (BTC) on poly(ionic\nliquid) (PIL)-based fibrous membranes. The Cu-BTC was grown in situ\non an imidazolium-based PIL fibrous membrane via coordination bonds,\nwhich increased the stability and dispersion of the Cu-BTC. The porous\nstructure of electrospinning and Cu-BTC allows the breathable dressings\nto absorb wound exudate and regulate the wound microenvironment. The\nimidazolium-based IL and Cu<sup>2+</sup> released from Cu-BTC endow\nthe dressing with effective bactericidal activities both <i>in\nvitro</i> and <i>in vivo</i>, especially for Cu-BTC<sub>60</sub>/PIL, in which more than 96% of bacteria are inactivated.\nMoreover, an <i>in vivo</i> bacterial infection wound study\nrevealed that the dressing with good biocompatibility can effectively\nsterilize Staphylococcus aureus while\nsuppressing inflammation and promoting wound healing. The developed\nwound dressing synergistically combines the antibacterial therapeutic\neffect of PIL and the release of Cu<sup>2+</sup> from Cu-BTC for effective\nwound healing, which may provide an ideal clinical intervention strategy\nfor infected wounds.