Amino Acid and Au(III)\nSelf-Assembled Supramolecular\nNanozymes for Antimicrobial Applications

The construction of highly catalytic nanozymes that are\ncomposed\nof biomolecules remains a difficulty due to complicated synthesis\nmethods and poor catalytic efficiencies. In this study, the authors\nfabricated noble metal ion supramolecular nanospheres (Fmoc-His-Au)\nthrough the combination of electrostatic adsorption and multifarious\nweak intermolecular force between AuCl<sub>4</sub><sup>–</sup> and amphipathic histidine. The synthesis procedure is extremely\nsimple and easy, and the noncovalent bond interactions between amphiphilic\nhistidine and AuCl<sub>4</sub><sup>–</sup> facilitated the\nconstitution of supramolecular nanostructures and simultaneously stabilized\nthe highly active AuCl<sub>4</sub><sup>–</sup> center, which\nexhibited great peroxidase (POD)- and oxidase (OXD)-like capacities\nthat could efficaciously transform the dissolved oxygen and H<sub>2</sub>O<sub>2</sub> to reactive oxygen species (ROS). In addition,\nthis simple and innovative nanozyme displayed a preeminent antibacterial\nand wound healing performance both for Staphylococcus\naureus and Escherichia coli bacteria in vitro and in vivo, with the bacteria inhibition percentage\nof over 98% for S. aureus and E. coli, and exhibited benign biocompatibility and\nlow toxicity. This study paves the way for designing outstanding catalytic\nenzyme-like supramolecular nanostructures composed of simple amino\nacids and metal ions for wide nanomedical and pharmaceutical applications.