Chemoselective Synthesis of α‑Tertiary\nHydroxy Oximes via Photochemical 1,3-Boronate Rearrangement

Tertiary\nalcohols with adjacent nucleophilic labile groups are\nprevalent in bioactive molecules but are challenging to synthesize.\nHerein we introduce a direct, protecting group-free method to access\nα-tertiary hydroxy oximes via photochemical 1,3-boronate rearrangement.\nThis reaction delivers high yields (up to 94%) using readily available\nboronic acids, is scalable to gram quantities, and allows for further\nderivatization to other nitrogen-containing molecules.