Palladium-CatalyzedDecarbonylative C–H Difluoromethylationof Azoles
A (XantPhos)Pd-catalyzed decarbonylative C–H functionalization of azoles with difluoromethyl anhydrides is reported. Under the optimized conditions, azole substrates react selectively at the C(2)-position to afford CF<sub>2</sub>H-substituted benzoxazole, oxazole, benzothiazole, thiazole, and benzimidazole products. Organometallic mechanistic studies reveal that XantPhos enforces an unusual seesaw geometry of the key Pd<sup>II</sup>(CF<sub>2</sub>H)(carboxylate) intermediate, which may be responsible for the effectiveness of this ligand.
Publication Details
- Journal
- Figshare
- Published
- 2025-07-23
- DOI
- https://doi.org/10.1021/acs.orglett.5c02175.s001
- Primary Topic
- Mycorrhizal Fungi and Plant Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00