Development\nof Glycosylation Protocols Using Glycosyl <i>N</i>‑Phenylethynyl\nPyrrole-2-carboxylates as Donors

We herein introduce glycosyl <i>N</i>-phenylethynyl\npyrrole-2-carboxylates\n(PEPCs) as novel and highly efficient glycosyl donors. The unique\ninclusion of the pyrrole group, serving as both an electron-donating\ngroup and an <i>ortho</i>-tethering scaffold, imparts exceptional\nshelf stability while retaining reactivity for glycosylation reactions.\nPEPC donors exhibit broad utility for both <i>O</i>- and <i>N</i>-glycosylation across a variety of substrates. Additionally,\ntheir versatility and efficiency were further demonstrated in a one-pot\nsaccharide synthesis, showcasing their potential for diverse synthetic\napplications.