Photothermal and\nAntibacterial PDA@Ag/SerMA Microneedles\nfor Promoting Diabetic Wound Repair

Diabetic foot ulcer (DFU) is a common and severe complication\nof\ndiabetes characterized by wound neuropathy, ischemia, and susceptibility\nto infection, making its treatment difficult. Dressings are commonly\nused in treating diabetic wounds; however, they have disadvantages,\nincluding lack of flexibility and mechanical strength, lack of coagulation\nactivity, resistance to biodegradation, and low drug delivery efficiency.\nDeveloping more effective strategies for diabetic wound treatment\nhas become a new focus. Microneedles (MN) can be used as a drug delivery\nplatform for DFU wounds, allowing safe, effective, painless and minimally\ninvasive medication administration through the skin. Herein, PDA@Ag/SerMA\nmicroneedles were prepared by combining the photothermal properties\nof polydopamine (PDA), the antimicrobial properties of argentum (Ag),\nand the ability of sericin methacryloyl (SerMA) to promote cell mitosis\nto accelerate wound healing and treat diabetic ulcer wounds. The results\nrevealed that PDA@Ag/SerMA microneedles exhibited approximately 100%\nantimicrobial efficacy against Staphylococcus aureus and Escherichia coli under 808 nm\nnear-infrared (NIR) irradiation. Furthermore, the wound healing rate\nof mice reached 95% within 12 days, which demonstrated the excellent\nantibacterial properties and wound healing efficacy of PDA@Ag/SerMA\nmicroneedles at cellular and animal levels, providing a potential\nsolution for treating DFU.