Deep Eutectic\nSolvents Coated with Glycoside Surfactants-Based\nNovel Micelles for Simultaneous Extraction and In Situ Enrichment\nof Natural Phenolic Compounds in One Extraction Process

Herein,\na rapid, effective, and environmentally friendly\nmethod\nutilizing deep eutectic solvents (DES) coated with glycoside surfactants\nwas developed for the extraction of phenolic compounds in ginger peel.\nThis method employs ultrahigh-performance liquid chromatography with\na diode array detector. Following single-factor optimization, the\nresponse surface methodology was employed to further refine the extraction\nconditions. Results demonstrated that the maximum yield of total gingerols\nwas achieved under the following conditions: a lauryl glucoside concentration\nof 62.1 mM, a DES volume of 0.92 mL, and a pH of 6.49. Additionally,\nthe new technique provided satisfactory recoveries for the analytes\nin ginger peel samples (84.940–110.77%), low limits of detection\n(0.0441–0.0681 μg/mL), and calibration curve linearity\ncharacterized by the <i>R</i><sup>2</sup> values exceeding\n0.99, along with excellent precision. Consequently, the proposed method\nof glycoside surfactant–coated DES presents an eco-friendly\nand efficient approach for extracting natural compounds with varying\npolarities from complex plant materials.