Thermodynamically\nTemplated Macrocyclizations: Enhancing\nthe Synthesis of Prism[5]arenes with Tailor-Made Guests

The macrocyclization of 2,6-dialkoxynaphthalene monomers\nto prism[5]arenes\nis thermodynamically templated by DABCO cations. In this study, we\ndemonstrate that a greater template affinity for prism[5]arene improves\nthe macrocyclization yield. By using novel templating cations, the\nyield of alkoxy-prism[5]arenes increases significantly compared with\nthose of previously reported procedures, while the purification process\nbecomes easier and faster.