Conversion of\nCarboxylic Acids to Sulfonamide Bioisosteres\nvia Energy Transfer Photocatalysis

More than 450 drugs containing a carboxylic acid functional\ngroup\nhave been marketed worldwide. Herein, we report a concise and environmentally\nfriendly organic photoinduced protocol for the interconversion of\n carboxylic acids into their bioisosteres. With this strategy, a variety\nof substrates, including alkyl, (hetero)aryl, and alkenyl acids, as\nwell as various biologically relevant acids are successfully converted\ninto primary sulfonamides.