Copper-Catalyzed\nDifluoromethylation of Alkenyl Thianthrenium\nSalts

We have developed a novel and straightforward protocol\nthat facilitates\nthe transformation of alkenylsulfonium salts leading to the direct\nsynthesis of <i>E</i>-difluoromethylated alkenes. The success\nof this method relies on the use of copper catalysis and Vicic–Mikami\nreagent (DMPU)<sub>2</sub>Zn(CF<sub>2</sub>H)<sub>2</sub>. These mild\nprotocols offer the advantage of selectively synthesizing either aromatic\nor aliphatic difluoromethylated alkenes. Furthermore, our methodology\nextends to the perfluoroalkylation of alkenylsulfonium salts. Notably,\nthis approach is conducive to large-scale synthesis and holds promise\nfor diverse applications.