Phytochemical profiling and evaluation of antimicrobial properties of Papilionanthe teres leaves extracts and their green synthesized silver nanoparticles

The study was performed to investigate the phytochemical profile and antimicrobial activity of Papilionanthe teres leaves (PTL) and their synthesized silver nanoparticles (AgNPs-PTL). Preliminary phytochemical profiling confirmed the presence of flavonoids, phenols, triterpenoids, steroids, and carbohydrates that can exert various pharmacological activities. Further, comprehensive GC-MS and HPTLC analyses identified the presence of 56 and 4 bioactive compounds, respectively. Characterization techniques like UV-Vis spectroscopy, FTIR, XRD, SEM, DLS, and EDX verified the crystalline structure, spherical shape, and nanosize of AgNPs-PTL. Silver nanoparticles synthesized using P. teres leaves extract (AgNPs-PTL) exhibited strong antimicrobial activity compared to the plant extract alone. AgNPs-PTL exhibited higher antimicrobial activity against E. coli than S. aureus, highlighting their biomedical relevance. So, this research highlights the significant antimicrobial potential of P. teres leaves and their green-synthesized silver nanoparticles, emphasizing their eco-friendly, cost-effective, and green synthesis. These findings support the development of novel medications to improve human health, validating the medicinal value of the P. teres plant and its AgNPs-PTL in treating microbial infections and their associated diseases and promoting sustainable drug development. • Phytochemical profiling of Papilionanthe teres leaves using GC-MS and HPTLC. • Green synthesis of AgNPs from the leaves of Papilionanthe teres . • The green synthesized AgNPs were characterized by UV, FTIR, DLS, XRD, EDX, and SEM. • Green-synthesized AgNPs showed potent antimicrobial properties.