Hypomethylation of the p53 and p16 suppressor genes in cellular aging

\nProtein p53, a product of p53 gene expression, protects the integrity of the genome throughout life and promotes the cell repair in the process of cell aging. In this review, the fundamental significance of the p53 gene was analyzed in the cell aging. The review showed that hypomethylation of the promoter region of the p53 and p16 suppressor genes occurs during aging; the DNA hypomethylation is explained by the possible age-related decrease in the content of CH3-groups donor (S-adenosyl monophosphate) in the cell, and by the activity of DNA methyltransferases.\n

Publication Details

Journal
Springer Link (Chiba Institute of Technology)
Published
2024-11-28
DOI
https://doi.org/10.1051/bioconf/202414901050/pdf
Primary Topic
Mycorrhizal Fungi and Plant Interactions
Type
article
Field-Weighted Citation Impact
0.00
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article

Hypomethylation of the p53 and p16 suppressor genes in cellular aging

Springer Link (Chiba Institute of Technology)
Mycorrhizal Fungi and Plant Interactions
article

Hypomethylation of the p53 and p16 suppressor genes in cellular aging

article en

Abstract

\nProtein p53, a product of p53 gene expression, protects the integrity of the genome throughout life and promotes the cell repair in the process of cell aging. In this review, the fundamental significance of the p53 gene was analyzed in the cell aging. The review showed that hypomethylation of the promoter region of the p53 and p16 suppressor genes occurs during aging; the DNA hypomethylation is explained by the possible age-related decrease in the content of CH3-groups donor (S-adenosyl monophosphate) in the cell, and by the activity of DNA methyltransferases.\n

Springer Link (Chiba Institute of Technology)
Openalex Percentile: Top 61%
Mycorrhizal Fungi and Plant Interactions
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Hypomethylation of the p53 and p16 suppressor genes in cellular aging · Springer Link (Chiba Institute of Technology) (2024) | TGRS Research Map | TGRS