HFIP-Promoted AromaticElectrophilic Amidation ofIndoles and Pyrroles with Isocyanates

A mild and practical method for synthesizing amidoindoles and amidopyrroles was described via the direct amidation of indoles or pyrroles with isocyanates promoted by 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). In this reaction, HFIP acted as a strong hydrogen bond-donating solvent to activate isocyanates, enabling the amidation of electron-rich nitrogen-containing heterocycles.

Publication Details

Journal
Figshare
Published
2025-03-19
DOI
https://doi.org/10.1021/acs.joc.4c03176.s001
Primary Topic
Mycorrhizal Fungi and Plant Interactions
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

HFIP-Promoted AromaticElectrophilic Amidation ofIndoles and Pyrroles with Isocyanates

Figshare
Mycorrhizal Fungi and Plant Interactions
article

HFIP-Promoted AromaticElectrophilic Amidation ofIndoles and Pyrroles with Isocyanates

article en

Abstract

A mild and practical method for synthesizing amidoindoles and amidopyrroles was described via the direct amidation of indoles or pyrroles with isocyanates promoted by 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). In this reaction, HFIP acted as a strong hydrogen bond-donating solvent to activate isocyanates, enabling the amidation of electron-rich nitrogen-containing heterocycles.

Figshare
Clean water and sanitation
Openalex Percentile: Top 54%
Mycorrhizal Fungi and Plant Interactions
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

HFIP-Promoted AromaticElectrophilic Amidation ofIndoles and Pyrroles with Isocyanates · Figshare (2025) | TGRS Research Map | TGRS