Site-Selective Gold-Catalyzed Alkylation of α‑Aminotropones\nwith Allenes

The\nsite-selective alkylation of α-aminotropones is effectively\nrealized via gold(I)-catalyzed electrophilic activation of allenamides\nand allenyl ethers, yielding up to 85% in 30 examples. A dedicated\nand combined spectroscopic and computational investigation accounts\nfor both chemo- and regioselective profiles of the protocol. New opportunities\nin the chemical space of tropone/tropolone derivatives are identified.