Synthesis of Fused Bicyclic\n[1,2,4]-Triazoles from\nAmino Acids

A 3-step\nmodular procedure combining carboxylic acids with acyl\nhydrazines provides access to medicinally relevant [1,2,4]-fused triazoles.\nGood to excellent yields are achieved with tolerance of aliphatic\nand aryl substituents as well as 5-, 6-, and 7-membered rings for\nthe fused ring. Conditions that can avoid column chromatography and\nbe applicable for both small scale discovery efforts as well as large\nscale development processes are demonstrated within.