Coordination-Driven\nin Situ Grown Copper Peroxide\nin Mesoporous Dopamine with Self-Supplied H<sub>2</sub>O<sub>2</sub> for Synergistic Enhanced PTT/CDT Antibacterial Treatment and Wound\nHealing

As\nantibiotic resistance increases, alternative antimicrobial\nmethods\nbecome essential. Chemical dynamics therapy (CDT) utilizing copper\nperoxide (CuO<sub>2</sub>) nanodots shows significant potential in\nantibacterial applications due to its ability to self-supply hydrogen\nperoxide (H<sub>2</sub>O<sub>2</sub>) on its own. This characteristic\neffectively addresses the challenges of low H<sub>2</sub>O<sub>2</sub> levels and high glutathione (GSH) expression in the bacterial infection\nmicroenvironment. However, its tendency to aggregate and instability\n greatly affect its effectiveness. Therefore, this study developed\na coordination-driven strategy to prepare copper peroxide-loaded mesoporous\npolydopamine nanomaterials (CuO<sub>2</sub>@MPDA) through in situ\ngrowth of CuO<sub>2</sub> in mesoporous polydopamine utilizing the\nchelating interaction between amino and catechol structures of MPDA\nwith copper ions. This strategy not only ensures that copper peroxide\nis evenly distributed within the pores of mesoporous polydopamine\nbut also protects it through the shielding effect of pores, greatly\nenhancing its dispersibility and stability. More notably, the loading\nof CuO<sub>2</sub> enhances the photothermal performance of MPDA by\nbroadening its light absorption range, and MPDA-mediated photothermal\ntherapy (PTT) can accelerate CuO<sub>2</sub> to produce more hydroxyl\nradicals by speeding up chemical reactions, resulting in a combined\nboost in PTT and CDT. The developed CuO<sub>2</sub>@MPDA nanomaterials\nat very low concentrations exhibit improved antibacterial efficiency\nboth in vitro and in vivo. Overall, this study provides an innovative\nstrategy to construct an antibacterial nanoplatform for synergistically\nenhanced PTT/CDT dual-mode antibacterial treatment, exhibiting great\npotential for future biomedical applications.