Ruthenium-CatalyzedRemote Trifunctionalization ofNon-Activated Alkenes via Cyano Migration and <i>meta</i>-C(sp²)–H Functionalization

A novel Ru-catalyzed radical-triggered trifunctionalization of hexenenitriles is presented, employing a strategy of remote cyano group migration and <i>meta</i>-C(sp²)–H functionalization. Through remote cyano migration, the alkenyl moiety undergoes difunctionalization to the formation of a benzylic radical intermediate. This intermediate facilitates <i>para</i>-selective C–H bond addition relative to the C–Ru bond within the Ru(III) complex, ultimately enabling trifunctionalization. This methodology provides an efficient route to a diverse array of nitrile-containing compounds with broad functional group compatibility.