Photocatalytic\nDecarboxylative Allylation of α‑Amino\nAcids and Peptides under Metal-Free Conditions

We developed an organophotoredox catalytic system to\nfacilitate\nthe decarboxylative allylation coupling process concerning α-amino\nacids and related C-terminal carboxylate peptides using Morita–Baylis–Hillman\nadducts as allylic precursors. This metal-free method operates under\nmild conditions and is compatible with various amino acids. The versatility\nof this protocol, particularly in chemical biology research, has been\npreliminarily demonstrated through the ligation of bioactive peptide\nchains.