Nickel-CatalyzedHydrocarbamoylation of Alkenes withIsocyanates

The hydrocarbamoylation of alkenes with isocyanates is a promising method for synthesizing amides. However, applying this strategy to more inert, simple alkenes, such as styrenes, α-olefins, and internal alkenes, poses significant challenges. Here, we report the first nickel-catalyzed hydrocarbamoylation of alkenes with isocyanates, facilitated by triethoxysilane to reduce nickelacycle intermediates. By switching ligandsincluding 6,6′-dimethyl-2,2′-bipyridine and <i>N</i>-heterocyclic carbenethis method efficiently produces amides from a diverse array of alkenes, including styrenes, α-olefins, internal alkenes, and gaseous olefins.