Aggregation-Induced\nEmission Luminogen Based Wearable\nVisible-Light Penetrator for Deep Photodynamic Therapy

Photodynamic therapy (PDT) has emerged as a preferred\nnonsurgical\ntreatment in clinical applications due to its capacity to selectively\neradicate diseased tissues while minimizing damage to normal tissue.\nNevertheless, its clinical efficacy is constrained by the limited\npenetration of visible light. Although near-infrared (NIR) lasers\noffer enhanced tissue penetration, the dearth of suitable photosensitizers\nand a pronounced imaging-treatment disparity pose challenges. Additionally,\nclinical implementation via optical fiber implantation carries infection\nrisks and necessitates minimally invasive surgery, contradicting PDT’s\nnoninvasive advantage. In this study, we introduce a brilliant approach\nutilizing aggregation-induced emission luminogens (AIEgen) to develop\na visible-light penetrator (VLP), coupled with wireless light emitting\ndiodes (LEDs), enabling deep photodynamic therapy. We validate the\ntherapeutic efficacy of this visible-light penetrator in tissues inaccessible\nto conventional PDT, demonstrating significant suppression of inflammatory\ndiffusion <i>in vivo</i> using AIEgen TBPPM loaded within\nthe VLP, which exhibits a transmittance of 86% in tissues with a thickness\nof 3 mm. This innovative visible-light penetrator effectively overcomes\nthe substantial limitations of PDT in clinical settings and holds\npromise for advancing phototherapy.