Triflic Anhydride-Mediated\nUnprecedented Reactivities\nof Diacetonide Endoglucofuranose and Ribose Tetracetate: Direct Access\nto γ‑Butenolides and Oxazoles

Herein, we present two unprecedented\nreactions for the\nsynthesis\nof γ-butenolides and oxazoles, leveraging Tf<sub>2</sub>O’s\npromoted reactivity of nitriles with diacetonide endoglucofuranose\nand 1,2,3,5-tetra-<i>O</i>-acetyl-β-d-ribofuranose.\nThis method is highly efficient and straightforward and employs a\none-step, metal-free protocol. It is effective with both aromatic\nand aliphatic nitriles and demonstrates a broad substrate scope. Our\napproach provides a versatile and practical pathway for the synthesis\nof structurally diverse compounds, significantly expanding the utility\nof Tf<sub>2</sub>O in synthetic chemistry.