Pd-Catalyzed\n1,4-Difluoromethylative Functionalization\nof 1,3-Dienes Using Freon-22

We report a visible-light-driven, palladium-catalyzed\n1,4-difluoromethylative\nfunctionalization of conjugated dienes using chlorodifluoromethane\n(ClCF<sub>2</sub>H, Freon-22) as a cost-effective difluoromethyl source.\nThe excited palladium catalyst efficiently reduces the C–Cl\nbond, which generates a CF<sub>2</sub>H radical, followed by regioselective\nS<sub>N</sub>2’ substitution to afford 1,4-difunctionalized\nproducts. This versatile, redox-neutral method accommodates diverse\nnucleophiles and exhibits broad functional group compatibility, making\nit suitable for late-stage functionalization in drug discovery and\noffering a direct route to difluoromethylated molecules.