Solubility of Perindopril l‑Arginine\nin 10 Pure Solvents and 3 Binary Solvents from 278.15 to 323.15 K

The\nsolubility of Perindopril l-Arginine was measured\nin ten pure solvents (water, methanol, ethanol, methyl ethyl ketone,\nisopropyl acetate, ethyl acetate, isobutyl acetate, <i>n</i>-propyl acetate, methyl <i>tert</i>-butyl ether, and methylcyclohexane)\nas well as in three binary solvent mixtures (methyl <i>tert</i>-butyl ether-water, methyl <i>tert</i>-butyl ether-methanol,\nand methyl <i>tert</i>-butyl ether-ethanol). These measurements\nwere conducted using isothermal methods of the dynamic method across\na temperature range of 278.15 to 323.15 K at a pressure of 0.1 MPa.\nThe solubility data in pure solvents were analyzed using the modified\nApelblat equation, Yaws equation, and Van’t Hoff equation.\nFor the binary solvent mixtures, the data were correlated by using\nthe improved Apelblat equation, the CNIBS/R-K model, and the Apelblat–Jouyban–Acree\nmodel. The calculated results from these models showed high agreement\nwith the experimental data, confirming the reliability of these models.