A new isoprenyl-phenol-type meroterpenoid from mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-Y65

Asperphenol A (<b>1</b>), a new isoprenyl-phenol-type meroterpenoid, was isolated from the mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-Y65 together with five known compounds (<b>2</b>-<b>6)</b>. All structures were assigned using extensive NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds <b>1-6</b> were evaluated for their cytotoxic activity against A549 and T24 human cancer cell lines. Among them, compounds <b>1</b> and <b>5</b> exhibited moderate inhibitory activities against T24 cancer cell lines with the IC₅₀ values of 26.71 and 43.50 μM, respectively.