Bioelectronic Medicine - Engineering the Body's Electrical Language for Health

Background: Hemorrhoids are a common anorectal condition characterized by inflammation, pain, and bleeding. Conventional treatments often carry side effects, prompting interest in herbal alternatives. Polyherbal formulations offer a synergistic therapeutic approach with fewer adverse effects. Methods: A polyherbal tablet containing Cissampelos pareira, Fagonia cretica, Terminalia chebula, and Berberis aristata was prepared by direct compression. A topical hydrogel incorporating Curcuma longa, Moringa oleifera, and Senna alexandrina was formulated using Carbopol 940. Both dosage forms were evaluated for standard physicochemical parameters. Safety was assessed via acute oral toxicity and rectal irritation tests. Results: The tablet showed good flowability (angle of repose 33.46°), acceptable hardness (6.5 kg/cm²), and disintegration within 7 minutes. The hydrogel had optimal pH (6.3), viscosity (18.4 Pa·s), and no signs of irritation. All formulations met pharmacopeial quality standards. Acute toxicity studies confirmed safety at therapeutic doses. Conclusion: The developed polyherbal formulations are safe, stable, and potentially effective for hemorrhoid management.